Journal article
Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries
Abstract
BACKGROUND: Genetic risk factors for dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and dengue fever (DF) are limited, in particular there are sparse data on genetic risk across diverse populations.
METHODS: We conducted a genome-wide association study (GWAS) in a derivation and validation sample of 7, 460 participants of Latin American, South Asian, and South East Asian ancestries. We then developed a weighted polygenic risk score …
Authors
Pare G; Neupane B; Eskandarian S; Harris E; Halstead S; Gresh L; Kuan G; Balmaseda A; Villar L; Rojas E
Journal
EBioMedicine, Vol. 51, ,
Publisher
Elsevier
Publication Date
January 2020
DOI
10.1016/j.ebiom.2019.11.045
ISSN
2352-3964