Quantitative susceptibility mapping based hybrid feature extraction for diagnosis of Parkinson's disease

Parkinson's disease is the second most common neurodegenerative disease in the elderly after Alzheimer's disease. The aetiology and pathogenesis of Parkinson's disease (PD) are still unclear, but the loss of dopaminergic cells and the excessive iron deposition in the substantia nigra (SN) are associated with the pathophysiology. As an imaging technique that can quantitatively reflect the amount of iron deposition, Quantitative Susceptibility …