Journal article
Association of Baclofen With Encephalopathy in Patients With Chronic Kidney Disease
Abstract
IMPORTANCE: At least 30 case reports have linked the muscle relaxant baclofen to encephalopathy in patients with chronic kidney disease (CKD).
OBJECTIVE: To compare the 30-day risk of encephalopathy in patients with CKD and newly prescribed baclofen at greater than or equal to 20 mg per day vs less than 20 mg per day. The secondary objective was to compare the risk of encephalopathy in baclofen users vs nonusers.
Authors
Muanda FT; Weir MA; Bathini L; Blake PG; Chauvin K; Dixon SN; McArthur E; Sontrop JM; Moist L; Garg AX
Journal
JAMA: The Journal of the American Medical Association, Vol. 322, No. 20, pp. 1987–1995
Publisher
American Medical Association (AMA)
Publication Date
November 26, 2019
DOI
10.1001/jama.2019.17725
ISSN
0098-7484