Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood Academic Article uri icon

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abstract

  • OBJECTIVE: The relationship between acute pancreatitis and incident diabetes is unclear. We assessed whether a resolved single event of acute pancreatitis in childhood was associated with incident diabetes in adulthood. RESEARCH DESIGN AND METHODS: A nationwide, population-based study of 1,802,110 Israeli adolescents (mean age 17.4 years [range 16-20]) who were examined before compulsory military service between 1979 and 2008 and whose data were linked to the Israeli National Diabetes Registry (INDR). Resolved pancreatitis was defined as a history of a single event of acute pancreatitis with normal pancreatic function at enrollment. Logistic regression analysis was applied. RESULTS: Incident diabetes developed in 4.6% of subjects with resolved pancreatitis (13 of 281; none of these cases were identified as type 1 diabetes) and 2.5% among the unexposed group (44,463 of 1,801,716). Resolved acute pancreatitis was associated with incident diabetes with an odds ratio (OR) of 2.23 (95% CI 1.25-3.98) with adjustment for age, sex, and birth year. Findings persisted after further adjustments for baseline BMI and sociodemographic confounders (OR 2.10 [95% CI 1.15-3.84]). Childhood pancreatitis was associated with a diagnosis of diabetes at a younger age, with 92% of diabetes case subjects diagnosed before 40 years of age compared with 47% in the unexposed group (P = 0.002). The association accentuated when the study sample was limited to individuals of unimpaired health or normal BMI at baseline. CONCLUSIONS: A history of acute pancreatitis in childhood with normal pancreatic function in late adolescence is a risk factor for incident type 2 diabetes, especially at young adulthood.

authors

  • Bendor, Cole D
  • Bardugo, Aya
  • Zucker, Inbar
  • Cukierman-Yaffe, Tali
  • Lutski, Miri
  • Derazne, Estela
  • Shohat, Tammy
  • Mosenzon, Ofri
  • Tzur, Dorit
  • Sapir, Ari
  • Pinhas-Hamiel, Orit
  • Kibbey, Richard G
  • Raz, Itamar
  • Afek, Arnon
  • Gerstein, Hertzel Chaim
  • Tirosh, Amir
  • Twig, Gilad

publication date

  • January 2020