Journal article
SHORT COMMUNICATION: DNA adduct formation in primary rabbit tracheal epithelial cells following treatment with 1, 8-dinitropyrene and its partially reduced derivative, 1-nitro-8-nitrosopyrene
Abstract
Formation of DNA adducts, following treatment of primary rabbit tracheal epithelial cells (RTEC) with 1,8-dinitropyrene (1,8-DNP) and its partially reduced derivative, 1-nitro-8-nitrosopyrene (1,8-NONO2), was examined using the 32P-post-labelling technique. Treatment of aerobic cells with 1,8-DNP or 1,8-NONO2 produced qualitatively similar results. Cochromatography showed that the major adduct observed corresponded to the major adduct seen …
Authors
Norman CA; Lambert IB; Davison LM; Bryant DW; McCalla DR
Journal
Carcinogenesis, Vol. 10, No. 7, pp. 1323–1327
Publisher
Oxford University Press (OUP)
Publication Date
1989
DOI
10.1093/carcin/10.7.1323
ISSN
0143-3334