Conference
A Humanized Zebrafish Transplant Model Expressing CXCL12 Provides an Enhanced In Vivo Therapeutic Screening Platform for T-ALL
Abstract
Abstract
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia and accounts for approximately 15% of all pediatric ALL cases. Outcomes have improved with contemporary chemotherapy regimens, however, they remain inferior to the 90% survival rates now observed for B-immunophenotype ALL. Perturbations in several signaling pathways, such as the NOTCH and PI3-kinase pathways, have been found to contribute to the …
Authors
Rajan V; Melong N; Campbell CJ; Dellaire G; Berman JN
Volume
126
Publisher
American Society of Hematology
Publication Date
December 3, 2015
DOI
10.1182/blood.v126.23.4273.4273
Conference proceedings
Blood
Issue
23
ISSN
0006-4971