Journal article
Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells
Abstract
BACKGROUND & AIMS: T-regulatory (Treg) cells suppress the immune response to maintain homeostasis. There are 2 main subsets of Treg cells: FOXP3 (forkhead box protein 3)-positive Treg cells, which do not produce high levels of effector cytokines, and type 1 Treg (Tr1) cells, which are FOXP3-negative and secrete interleukin (IL) 10. IL10 is an anti-inflammatory cytokine, so Tr1 cells might be used in the treatment of inflammatory bowel diseases. …
Authors
Cook L; Stahl M; Han X; Nazli A; MacDonald KN; Wong MQ; Tsai K; Dizzell S; Jacobson K; Bressler B
Journal
Gastroenterology, Vol. 157, No. 6, pp. 1584–1598
Publisher
Elsevier
Publication Date
December 2019
DOI
10.1053/j.gastro.2019.09.002
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedBiopsyCell CommunicationCell ProliferationCells, CulturedColitis, UlcerativeColonCrohn DiseaseFemaleForkhead Transcription FactorsHealthy VolunteersHumansInterleukin-10InterleukinsIntestinal MucosaMaleMiddle AgedPrimary Cell CultureT-Lymphocytes, CytotoxicT-Lymphocytes, RegulatoryInterleukin-22