Journal article
Detection of Tumor Antigen-Specific T-Cell Responses After Oncolytic Vaccination
Abstract
Oncolytic vaccines, which consist of recombinant oncolytic viruses (OV) encoding tumor-associated antigens (TAAs), have demonstrated potent antitumor efficacy in preclinical models and are currently evaluated in phase I/II clinical trials. On one hand, oncolysis of OV-infected malignant entities reinstates cancer immunosurveillance. On the other hand, overexpression of TAAs in infected cells further stimulates the adaptive arm of antitumor …
Authors
Pol JG; Bridle BW; Lichty BD
Journal
Methods in Molecular Biology, Vol. 2058, , pp. 191–211
Publisher
Springer Nature
Publication Date
2020
DOI
10.1007/978-1-4939-9794-7_12
ISSN
1064-3745