Journal article
Development and Validation of a Population-Pharmacokinetic Model for Rurioctacog Alfa Pegol (Adynovate®): A Report on Behalf of the WAPPS-Hemo Investigators Ad Hoc Subgroup
Abstract
Background and objectiveRurioctacog alfa pegol (Adynovate) is a modified recombinant factor VIII concentrate used for treating hemophilia A. Aiming to improve treatment tailoring on the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) platform for patients of all ages treated with Adynovate, we have developed and evaluated a population pharmacokinetic (PopPK) model. On the platform, PopPK models are used as priors for …
Authors
Chelle P; Yeung CHT; Croteau SE; Lissick J; Balasa V; Ashburner C; Park YS; Bonanad S; Megías-Vericat JE; Nagao A
Journal
Clinical Pharmacokinetics, Vol. 59, No. 2, pp. 245–256
Publisher
Springer Nature
Publication Date
February 2020
DOI
10.1007/s40262-019-00809-6
ISSN
0312-5963