Regression of Sebaceous Carcinoma of the Eyelid after a Small Incisional Biopsy: Report of Two Cases Academic Article uri icon

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  • Purpose: To report 2 cases of regression of sebaceous carcinoma of the eyelid after a small incisional biopsy. Methods: Clinical, imaging, and histopathological findings are presented, with a literature review on regressing ocular tumors. Results: Our first patient was a 79-year-old man who presented with a 10-month history of progressive left upper eyelid ptosis caused by an eyelid tumor with orbital involvement and confirmed on magnetic resonance imaging. Our second patient was a 70-year-old woman who presented with ptosis with a left upper eyelid mass. Both patients underwent a small incisional biopsy of their lesion. The histopathological diagnoses in both cases were consistent with sebaceous carcinoma. Both patients refused exenteration. Follow-up clinical examination and imaging disclosed total regression of the ptosis and of the neoplasm with no sign of recurrence in both patients over a 4-year period for Case 1 and a 7-year period for Case 2. Conclusion: Regression following incisional biopsy of basal cell, squamous cell, and Merkel cell carcinoma, including of the eyelid, is well documented. To the best of our knowledge, our 2 cases of sebaceous carcinoma are the first to be reported with total involution clinically and on imaging of the tumor following partial incisional biopsy.


  • Brownstein, Seymour
  • Mehta, Sonul
  • Nijhawan, Navdeep
  • Allaire, Guy
  • Nguyen, Tuan Quynh Tram
  • Tang, Tina
  • Jiang, Kailun
  • Saleh, Solin
  • Kalin-Hajdu, Evan
  • Bruen, Robbin
  • Oestrelcher, James

publication date

  • 2019