Sympathetic modulation of baseline hindlimb blood flow and vascular conductance in a model of prediabetes using young Zucker Diabetic Fatty rats

Although associated with vascular disease, few studies have addressed the impact of prediabetes on vascular function. Thus, we sought to identify differences in baseline sympathetic vascular control between male Zucker (pre)Diabetic Fatty rats (PD) and lean controls (CTL) (n = 11/group). Hindlimb blood flow (Q h ) and vascular conductance (VC) were assessed under local infusion of BIBP3226 (NPY Y 1 ‐receptor (Y1R) antagonist), prazosin (α 1 …