Clinical significance of the LacdiNAc‐glycosylated prostate‐specific antigen assay for prostate cancer detection Journal Articles uri icon

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  • AbstractTo reduce unnecessary prostate biopsies (Pbx), better discrimination is needed. To identify clinically significant prostate cancer (CSPC) we determined the performance of LacdiNAc‐glycosylated prostate‐specific antigen (LDNPSA) and LDNPSA normalized by prostate volume (LDNPSAD). We retrospectively measured LDNPSA, total PSA (tPSA), and free PSA/tPSA (F/T PSA) values in 718 men who underwent a Pbx in 3 academic urology clinics in Japan and Canada (Pbx cohort) and in 174 PC patients who subsequently underwent radical prostatectomy in Australia (preop‐PSA cohort). The assays were evaluated using the area under the receiver operating characteristics curve (AUC) and decision curve analyses to discriminate CSPC. In the Pbx cohort, LDNPSAD (AUC 0.860) provided significantly better clinical performance for discriminating CSPC compared with LDNPSA (AUC 0.827, P = 0.0024), PSAD (AUC 0.809, < 0.0001), tPSA (AUC 0.712, < 0.0001), and F/T PSA (AUC 0.661, < 0.0001). The decision curve analysis showed that using a risk threshold of 20% and adding LDNPSA and LDNPSAD to the base model (age, digital rectal examination status, tPSA, and F/T PSA) permitted avoidance of even more biopsies without missing CSPC (9.89% and 18.11%, respectively vs 2.23% [base model]). In the preop‐PSA cohort, LDNPSA values positively correlated with tumor volume and tPSA and were significantly higher in pT3, pathological Gleason score ≥ 7. Limitations include limited sample size, retrospective nature, and no family history information prior to biopsy. LacdiNAc‐glycosylated PSA is significantly better than the conventional PSA test in identifying patients with CSPC. This study was approved by the ethics committee of each institution (“The Study about Carbohydrate Structure Change in Urological Disease”; approval no. 2014‐195).


  • Yoneyama, Tohru
  • Tobisawa, Yuki
  • Kaneko, Tomonori
  • Kaya, Takatoshi
  • Hatakeyama, Shingo
  • Mori, Kazuyuki
  • Sutoh Yoneyama, Mihoko
  • Okubo, Teppei
  • Mitsuzuka, Koji
  • Duivenvoorden, Wilhelmina
  • Pinthus, Jehonathan
  • Hashimoto, Yasuhiro
  • Ito, Akihiro
  • Koie, Takuya
  • Suda, Yoshihiko
  • Gardiner, Robert A
  • Ohyama, Chikara

publication date

  • August 2019