Journal article
Pantoprazole to Prevent Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin in a Randomized, Double-Blind, Placebo-Controlled Trial
Abstract
BACKGROUND & AIMS: Antiplatelets and anticoagulants are associated with increased upper gastrointestinal bleeding. We evaluated whether proton pump inhibitor therapy could reduce this risk.
METHODS: We performed a 3 × 2 partial factorial double-blind trial of 17,598 participants with stable cardiovascular disease and peripheral artery disease. Participants were randomly assigned to groups given pantoprazole 40 mg daily or placebo, as well as …
Authors
Moayyedi P; Eikelboom JW; Bosch J; Connolly SJ; Dyal L; Shestakovska O; Leong D; Anand SS; Störk S; Branch KRH
Journal
Gastroenterology, Vol. 157, No. 2, pp. 403–412.e5
Publisher
Elsevier
Publication Date
8 2019
DOI
10.1053/j.gastro.2019.04.041
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Administration, OralAgedAnticoagulantsAspirinCardiovascular DiseasesDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFemaleGastrointestinal HemorrhageHumansMaleMiddle AgedPantoprazolePeptic UlcerProton Pump InhibitorsRivaroxabanTreatment Outcome