Journal article
α4-Integrin+ endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells
Abstract
The mechanism of commencement of hematopoiesis in blood islands of the yolk sac and the aorta-gonad-mesonephros (AGM) region during primate embryogenesis remains elusive. In this study, we demonstrated that VE-cadherin(+)CD45(-) endothelial cells derived from nonhuman primate embryonic stem cells are able to generate primitive and definitive hematopoietic cells sequentially, as revealed by immunostaining of floating erythrocytes and …
Authors
Shinoda G; Umeda K; Heike T; Arai M; Niwa A; Ma F; Suemori H; Luo HY; Chui DHK; Torii R
Journal
Blood, Vol. 109, No. 6, pp. 2406–2415
Publisher
American Society of Hematology
Publication Date
March 15, 2007
DOI
10.1182/blood-2006-06-031039
ISSN
0006-4971