Journal article
Embryonic ζ-Globin Chains in Adults: a Marker for α-Thalassemia-1 Haplotype Due to a >17.5-kb Deletion
Abstract
Hemolysates from adults with the alpha-thalassemia-1 haplotype due to the greater than 17.5-kb deletion of both alpha-globin genes from the same chromosome were found to contain embryonic zeta (zeta)-globin chains (alpha-globin-like chains), as determined by a specific and sensitive radioimmunoassay and an electrophoretic technique. zeta-Globin chains were not present in hemolysates from adults with deletion of a single alpha-globin gene from …
Authors
Chui DHK; Wong SC; Chung S-W; Patterson M; Bhargava S; Poon M-C
Journal
New England Journal of Medicine, Vol. 314, No. 2, pp. 76–79
Publisher
Massachusetts Medical Society
Publication Date
January 9, 1986
DOI
10.1056/nejm198601093140203
ISSN
0028-4793