Abnormal erythroid progenitor cells in human preleukemia Journal Articles

abstract

• Ten patients with preleukemia were studied by the erythroid cell clonal culture technique. In nine of these patients, erythroid colonies derived from peripheral blood BFU-E were not observed, while the other patient had markedly decreased peripheral blood BFU-E-derived erythroid colonies in vitro. In three patients, marrow cells were also cultured and no BFU-E-derived erythroid colonies were detected. These studies indicate that immature erythroid progenitor cells, BFU-E, in patients with preleukemia are either markedly decreased in number or grossly defective in their proliferative or differentiative capacities.

authors

• Chui, David Hing-kwei
• Clarke, BJ

status

• published 

publication date

• August 1, 1982

has subject area

• 1102 Cardiorespiratory Medicine and Haematology (FoR)
• 1103 Clinical Sciences (FoR)
• 1114 Paediatrics and Reproductive Medicine (FoR)
• Adult (MeSH)
• Aged (MeSH)
• Bone Marrow Cells (MeSH)
• Cell Separation (MeSH)
• Cells, Cultured (MeSH)
• Culture Media (MeSH)
• Dexamethasone (MeSH)
• Erythrocytes, Abnormal (MeSH)
• Female (MeSH)
• Hematopoietic Stem Cells (MeSH)
• Humans (MeSH)
• Immunology (Science Metrix)
• Male (MeSH)
• Middle Aged (MeSH)
• Preleukemia (MeSH)
• T-Lymphocytes (MeSH)

published in

• Blood  Journal

keywords

• Adult
• Aged
• Bone Marrow Cells
• Cell Separation
• Cells, Cultured
• Culture Media
• Dexamethasone
• Erythrocytes, Abnormal
• Female
• Hematopoietic Stem Cells
• Humans
• Male
• Middle Aged
• Preleukemia
• T-Lymphocytes

Digital Object Identifier (DOI)

• 10.1182/blood.v60.2.362.bloodjournal602362

PubMed ID

• 6980031

start page

• 362

end page

• 367

volume

• 60

issue

• 2