A Novel Sickle Hemoglobin: Hemoglobin S-South End Academic Article uri icon

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abstract

  • Sickle hemoglobin (Hb S; beta Glu6Val) is due to an AGTG; beta Lys132Asn, AAA>AAC). When present alone, the beta Lys132Asn mutation has low oxygen affinity. Therefore, this mutation may enhance the polymerization of the Hb S variant. Furthermore, the variant hemoglobin mimics Hb A on high-pressure liquid chromatography, and its identity is not easily diagnosed. A succinct review of variant sickle hemoglobins is also presented.

authors

  • Luo, Hong-yuan
  • Adewoye, Adeboye H
  • Eung, Shawn H
  • Skelton, Timothy P
  • Quillen, Karen
  • McMahon, Lillian
  • Steinberg, Martin H
  • Chui, David Hing-kwei

publication date

  • November 2004