Hemoglobin Titusville, a low oxygen affinity variant hemoglobin, in a family of Northern European background Academic Article uri icon

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  • We report the second case of Hb Titusville in a family of Northern European background. This variant hemoglobin caused by an alpha-globin gene mutation has decreased oxygen affinity. Correct diagnosis is clinically important to spare affected individuals extensive investigations into other causes of low oxygen saturation in peripheral blood.


  • Luo, Hong-yuan
  • Irving, Ian
  • Prior, John
  • Lim, Erna
  • Eung, Shawn H
  • Skelton, Timothy P
  • Erber, Wendy N
  • Steinberg, Martin H
  • Chui, David Hing-kwei

publication date

  • December 2004