Journal article
Fetal hemoglobin in sickle cell anemia
Abstract
Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin polymer. Fetal hemoglobin genes are genetically regulated, and the level of HbF and its distribution among sickle erythrocytes is highly variable. Some patients with sickle cell disease have exceptionally high levels of HbF that are associated with the Senegal and …
Authors
Akinsheye I; Alsultan A; Solovieff N; Ngo D; Baldwin CT; Sebastiani P; Chui DHK; Steinberg MH
Journal
Blood, Vol. 118, No. 1, pp. 19–27
Publisher
American Society of Hematology
Publication Date
July 7, 2011
DOI
10.1182/blood-2011-03-325258
ISSN
0006-4971