Journal article
Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials
Abstract
BACKGROUND: Increasing the dose intensity of cytotoxic therapy by shortening the intervals between cycles, or by giving individual drugs sequentially at full dose rather than in lower-dose concurrent treatment schedules, might enhance efficacy.
METHODS: To clarify the relative benefits and risks of dose-intense and standard-schedule chemotherapy in early breast cancer, we did an individual patient-level meta-analysis of trials comparing …
Authors
Gray R; Bradley R; Braybrooke J; Liu Z; Peto R; Davies L; Dodwell D; McGale P; Pan H; Taylor C
Journal
The Lancet, Vol. 393, No. 10179, pp. 1440–1452
Publisher
Elsevier
Publication Date
4 2019
DOI
10.1016/s0140-6736(18)33137-4
ISSN
0140-6736