The Vancouver 3M (Multidisciplinary, Multimodality, But Minimalist) Clinical Pathway Facilitates Safe Next-Day Discharge Home at Low-, Medium-, and High-Volume Transfemoral Transcatheter Aortic Valve Replacement Centers Academic Article uri icon

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abstract

  • OBJECTIVES: The authors sought to prospectively determine the safety and efficacy of next-day discharge using the Vancouver 3M (Multidisciplinary, Multimodality, but Minimalist) Clinical Pathway. BACKGROUND: Transfemoral transcatheter aortic valve replacement (TAVR) is an alternative to surgery in high- and intermediate-risk patients; however, hospital stays average at least 6 days in most trials. The Vancouver 3M Clinical Pathway is focused on next-day discharge, made possible by the use of objective screening criteria as well as streamlined peri- and post-procedural management guidelines. METHODS: Patients were enrolled from 6 low-volume (<100 TAVR/year), 4 medium-volume, and 3 high-volume (>200 TAVR/year) centers in Canada and the United States. The primary outcomes were a composite of all-cause death or stroke by 30 days and the proportion of patients successfully discharged home the day following TAVR. RESULTS: Of 1,400 screened patients, 411 were enrolled at 13 centers and received a SAPIEN XT (58.2%) or SAPIEN 3 (41.8%) valve (Edwards Lifesciences, Irvine, California). In centers enrolling exclusively in the study, 55% of screened patients were enrolled. The median age was 84 years (interquartile range: 78 to 87 years) with a median STS score of 4.9% (interquartile range: 3.3% to 6.8%). Next-day discharge home was achieved in 80.1% of patients, and within 48 h in 89.5%. The composite of all-cause mortality or stroke by 30 days occurred in 2.9% (95% confidence interval: 1.7% to 5.1%), with neither component of the primary outcome affected by hospital TAVR volume (p = 0.51). Secondary outcomes at 30 days included major vascular complication 2.4% (n = 10), readmission 9.2% (n = 36), cardiac readmission 5.7% (n = 22), new permanent pacemaker 5.7% (n = 23), and >mild paravalvular regurgitation 3.8% (n = 15). CONCLUSIONS: Adherence to the Vancouver 3M Clinical Pathway at low-, medium-, and high-volume TAVR centers allows next-day discharge home with excellent safety and efficacy outcomes.

authors

  • Wood, David A
  • Lauck, Sandra B
  • Cairns, John A
  • Humphries, Karin H
  • Cook, Richard
  • Welsh, Robert
  • Leipsic, Jonathon
  • Genereux, Philippe
  • Moss, Robert
  • Jue, John
  • Blanke, Philipp
  • Cheung, Anson
  • Ye, Jian
  • Dvir, Danny
  • Umedaly, Hamed
  • Klein, Rael
  • Rondi, Kevin
  • Poulter, Rohan
  • Stub, Dion
  • Barbanti, Marco
  • Fahmy, Peter
  • Htun, Nay
  • Murdoch, Dale
  • Prakash, Roshan
  • Barker, Madeleine
  • Nickel, Kevin
  • Thakkar, Jay
  • Sathananthan, Janarthanan
  • Tyrell, Ben
  • Al-Qoofi, Faisal
  • Velianou, James
  • Natarajan, Madhu K
  • Wijeysundera, Harindra C
  • Radhakrishnan, Sam
  • Horlick, Eric
  • Osten, Mark
  • Buller, Christopher
  • Peterson, Mark
  • Asgar, Anita
  • Palisaitis, Donald
  • Masson, Jean-Bernard
  • Kodali, Susheel
  • Nazif, Tamim
  • Thourani, Vinod
  • Babaliaros, Vasilis C
  • Cohen, David J
  • Park, Julie E
  • Leon, Martin B
  • Webb, John G

publication date

  • March 2019

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