Journal article
Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells
Abstract
To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammalian Argonaute (Ago) family of proteins, Ago1–4, into an effector complex known as the RNA-induced silencing complex (RISC). While the mature miRNA guides the RISC complex to its target mRNA, the Ago protein represses mRNA translation. The specific roles of the various Ago members in mediating miRNAs activity, however, haven’t been clearly …
Authors
Bellissimo T; Tito C; Ganci F; Sacconi A; Masciarelli S; Di Martino G; Porta N; Cirenza M; Sorci M; De Angelis L
Journal
Cell Death & Disease, Vol. 10, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41419-018-1267-5
ISSN
2041-4889