Journal article
The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia
Abstract
PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson's disease and haloperidol-induced extrapyramidal movement disorders. PAOPA's unique allosteric mechanism and dopamine D2 receptor specificity provide a unique composition of properties for the development of potential therapeutics for …
Authors
Daya RP; Bhandari J; Kooner SK; Ho J; Rowley CD; Bock NA; Farncombe T; Mishra RK
Journal
Frontiers in Behavioral Neuroscience, Vol. 12, ,
Publisher
Frontiers
DOI
10.3389/fnbeh.2018.00302
ISSN
1662-5153