Getting more out of meta-analyses: a new approach to meta-analysis in light of unexplained heterogeneity

BACKGROUND AND OBJECTIVES: Meta-analyses sometimes summarize results in the presence of substantial unexplained between-study heterogeneity. As GRADE criteria highlight, unexplained heterogeneity reduces certainty in the evidence, resulting in limited confidence in average effect estimates. The aim of this paper is to provide a new clinically useful approach to estimating an intervention effect in light of unexplained heterogeneity. METHODS: We …