Effects of chronic acetazolamide administration on gas exchange and acid‐base control in pulmonary circulation in exercising horses

REASONS FOR PERFORMING STUDY: Carbonic anhydrase (CA) catalyses the hydration/dehydration reaction of CO(2) and increases the rate of Cl(-) and HCO(3)(-) exchange between the erythrocytes and plasma. Therefore, chronic inhibition of CA has a potential to attenuate CO(2) output and induce greater metabolic and respiratory acidosis in exercising horses. OBJECTIVES: To determine the effects of Carbonic anhydrase inhibition on CO(2) output and …