Journal article
Characteristics and determinants of T‐cell phenotype normalization in HIV‐1‐infected individuals receiving long‐term antiretroviral therapy
Abstract
OBJECTIVES: Although combination antiretroviral therapy (cART) can restore CD4 T-cell numbers in HIV infection, alterations in T-cell regulation and homeostasis persist. We assessed the incidence and predictors of reversing these alterations with cART.
METHODS: ART-naïve adults (n = 4459) followed within the Canadian Observational Cohort and exhibiting an abnormal T-cell phenotype (TCP) prior to cART initiation were studied. Abnormal TCP was …
Authors
Ndumbi P; Gillis J; Raboud J; Cooper C; Hogg R; Montaner J; Burchell A; Loutfy; Machouf N; Klein M
Journal
HIV Medicine, Vol. 15, No. 3, pp. 153–164
Publisher
Wiley
Publication Date
March 2014
DOI
10.1111/hiv.12096
ISSN
1464-2662