Responses to Aggregating Agents after Cleavage of GPIb of Human Platelets by the O-Sialoglycoprotein Endoprotease from Pasteurella haemolytica— Potential Surrogates for Bernard-Soulier Platelets? \textbar Request PDF

Request PDF on ResearchGate \textbar Responses to Aggregating Agents after Cleavage of GPIb of Human Platelets by the O-Sialoglycoprotein Endoprotease from Pasteurella haemolytica— Potential Surrogates for Bernard-Soulier Platelets? \textbar Most proteolytic enzymes that cleave glycoprotein lb (GPlb) also cleave other glycoproteins or receptors on the surface of platelets. We have used an O-sialoglycoprotein endoprotease from Pasteurella haemolytica that selectively cleaves the heavily O-glycosylated GPlb, but... \textbar Keywords: Platelets, Pasteurella and Bernard-Soulier Syndrome