Biogenic amines and rabbit follicular testosterone production

Incubation of isolated rabbit follicles with epinephrine, norepinephrine, isoproterenol, phentolamine and propanolol at various doses from 0.1 to 1.0 μg/ml, failed to stimulate testosterone production. When used in combination with LH (5 μg/ml) phentolamine (100 μg/ml) enhanced (p < 0.05) and propanolol (100 μg/ml) depressed (p < 0.01) the testosterone response to LH alone. These data suggest that α and β blockers may modify follicular response to LH.