Factors associated with heterogeneity in microarray gene expression in peripheral blood mononuclear cells from large pedigrees

BackgroundGenome-wide microarray expression is a rich source of functional genomic data. We examined evidence for differences in expression from peripheral blood mononuclear cells between individuals, examined some of factors that may be responsible and provide recommendations for analysis.MethodsA total of 643 individuals from 17 large Mexican American pedigrees had microarray gene expression data generated from peripheral blood mononuclear …