Journal article
The Inotropic Effect of 4−Aminopyridine and pH Changes in Rabbit Papillary Muscle
Abstract
The effects of 4-aminopyridine (4AP), and pH changes have been examined on tension responses and cyclic nucleotide levels in rabbit isolated right ventricular papillary muscles. 4AP augmented papillary muscle contractions in a concentration-dependent manner. However, this positive inotropic action was largely due to an increase in extracellular pH produced by 4AP, rather than an intrinsic activity of the drug. Increases in extracellular pH …
Authors
Shahid M; Rodger IW
Journal
Journal of Pharmacy and Pharmacology, Vol. 41, No. 9, pp. 601–606
Publisher
Oxford University Press (OUP)
Publication Date
September 1, 1989
DOI
10.1111/j.2042-7158.1989.tb06539.x
ISSN
0022-3573