Journal article
Nicotinamide adenine dinucleotide depresses synaptic transmission in the hippocampus and has specific binding sites on the synaptic membranes
Abstract
The electrical activity of transverse slices of hippocampus was used as a bioassay in which extracts of fresh brain tissue were screened for biological activity. A factor that depressed synaptic transmission was identified as nicotinamide adenine dinucleotide (NAD). This depressant action of NAD could be observed at concentrations in the range 1-10 microM and the degree of depression was monotonically related to the concentration of NAD in the …
Authors
Richards CD; Snell CR; Snell PH
Journal
British Journal of Pharmacology, Vol. 79, No. 2, pp. 553–564
Publisher
Wiley
Publication Date
June 1983
DOI
10.1111/j.1476-5381.1983.tb11030.x
ISSN
0007-1188