Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson’s Disease Academic Article uri icon

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abstract

  • We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.

authors

  • Arora, Siddharth
  • Visanji, Naomi P
  • Mestre, Tiago A
  • Tsanas, Athanasios
  • AlDakheel, Amaal
  • Connolly, Barbara
  • Gasca-Salas, Carmen
  • Kern, Drew S
  • Jain, Jennifer
  • Slow, Elizabeth J
  • Faust-Socher, Achinoam
  • Lang, Anthony E
  • Little, Max A
  • Marras, Connie

publication date

  • October 17, 2018