The Formation of Diradylglycerol Molecular Species in Murine Peritoneal Macrophages Varies Dose-Dependently with Dietary Purified Eicosapentaenoic and Docosahexaenoic Ethyl Esters

Substantial effects of dietary fish oil-derived fatty acid ethyl esters on the metabolism of diradylglycerol (DG) have recently been described. We undertook to isolate the separate effects of (n-3) eicosapentaenoic acid (EPA) and (n-3) docosahexaenoic acid (DHA) on DG metabolism. For 3 wk, male C57BL/6 mice were fed one of six purified diets in which the lipid component was either 3 g/100 g corn oil ethyl ester (COEE) (control diet) or 1 g/100 …