Due to the impact and influence of information technology on the education, computer-assisted language learning is becoming the trend in engineering laboratory based teaching and learning. Furthermore, the interactive computer network allows students to explore the technical information and to conduct the laboratory activities more independently. In this research, we introduced a multimedia system to the undergraduate lab education in order to transform a traditional lab instruction to the dynamic experiential learning environment. We applied this multimedia method in a number of labs from second-year class to fourth-year class. Then we evaluate the effectiveness of this new lab teaching approach by conducting student survey and lab test. Based on the results of lab test, we will further measure the Course Learning Outcome (CLO) and Program Learning Outcome (PLO) from the classes with or without adopting this method. Since biotechnology is a discipline of applied science, laboratory application holds high importance in its education. In biotechnology, and other applied science labs, students enhance their learning through seeing, observing, and performing. Our research indicates that this multimedia approach can cultivate the teaching laboratory into more student-centered, active, challenge-based, self-directed learning, and problem based learning environment.