[OP.LB01.01] CARDIOVASCULAR RISK IN RELATION TO ACHIEVED AUTOMATED BLOOD PRESSURE IN CLINICAL PRACTICE

Objective: The results of the Systolic Blood Pressure Intervention Trial (SPRINT) have renewed interest in the optimum BP target for treated hypertension. Using automated office blood pressure (AOBP), SPRINT reported that treating to a target systolic BP of < 120 mmHg significantly reduced cardiovascular endpoints compared to the conventional target of < 140 mmHg. However, it is not yet known if and how these findings using AOBP can be integrated into clinical practice. Accordingly, we sought to examine the relationship between achieved AOBP on antihypertensive therapy and cardiovascular endpoints in a large cohort of community-dwelling, older Canadians. Design and method: The relationship between systolic AOBP and cardiovascular endpoints over a mean 4.6 years of follow-up was examined in 6,183 subjects aged > 65 years who were receiving anti-hypertensive medication at baseline. Adjusted hazard ratios (HR) with 95% confidence intervals (CI) were computed for 10 mmHg categories of achieved AOBP …