Journal article
Induction of Antibodies Protecting against Transmissible Gastroenteritis Coronavirus (TGEV) by Recombinant Adenovirus Expressing TGEV Spike Protein
Abstract
Ten recombinant adenoviruses expressing either fragments of 1135, 1587, or 3329 nt or the full-length spike gene of transmissible gastroenteritis coronavirus (TGEV) have been constructed. These recombinants produce S polypeptides with apparent molecular masses of 68, 86, 135, and 200 kDa, respectively. Expression of the recombinant antigen driven by Ad5 promoters was inhibited by the insertion of an exogenous SV-40 promoter. Most of the …
Authors
TORRES JM; SÁNCHEZ C; SUÑÉ C; SMERDOU C; PREVEC L; GRAHAM F; ENJUANES L
Journal
Virology, Vol. 213, No. 2, pp. 503–516
Publisher
Elsevier
Publication Date
11 1995
DOI
10.1006/viro.1995.0023
ISSN
0042-6822
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenoviruses, HumanAnimalsAntibodies, ViralAntigens, ViralCell LineCricetinaeFemaleGastroenteritis, Transmissible, of SwineGenetic VectorsHumansImmunization, PassiveMaleMembrane GlycoproteinsRecombinant ProteinsSpike Glycoprotein, CoronavirusSwineSwine, MiniatureTransmissible gastroenteritis virusVaccinationViral Envelope Proteins