The stability of protonT2 effects of oxygen-17 water in experimental cerebral ischemia Academic Article uri icon

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abstract

  • The gerbil model of unilateral cerebral ischemia has been used to test the temporal and spatial stability of the MRI T2 effects of oxygen-17 water. Following unilateral carotid ligation, symptomatic animals were given a single large intraperitoneal injection of H2(17)O and the distribution and stability of the brain T2 effects were followed with a spin-echo sequence. In contrast to the ischemic areas, the perfused tissue shows a marked and prolonged loss in intensity with little evidence of diffusion of the T2 effect of 17O into the ischemic tissue.

authors

  • Hopkins, AL
  • Lust, WD
  • Haacke, Mark
  • Wielopolski, P
  • Barr, RG
  • Bratton, CB

publication date

  • November 1991