Unusual Course of Congenital Hypothyroidism and Route of the L-Thyroxine Treatment in a Preterm Newborn Journal Articles uri icon

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  • Congenital hypothyroidism (CH) is the most common endocrine pathology in neonates. Inappropriate treatment of CH is complicated by irreversible brain damage or low IQ score. Hormone replacement therapy with L-thyroxine (L-T4) is sufficient for a very large proportion of patients. However, during treatment, the patient needs to be carefully monitored for presence of factors which might affect the absorption or bio-availability of the drug as well as its dose. Herein, we report a preterm newborn with CH who presented with gastrointestinal problems mimicking necrotizing enterocolitis. The clinical course was also complicated by cholestasis. The L-T4 replacement treatment was switched from oral route to parenteral. After resolution of the cholestasis, L-T4 treatment was continued successfully by the oral route.


  • Yikilmaz, Ali
  • Korkmaz, Levent
  • Akın, Mustafa Ali
  • Güneş, Tamer
  • Daar, Ghaniya
  • Baştuğ, Osman
  • Yıkılmaz, Ali
  • Kurtoğlu, Selim

publication date

  • September 5, 2014