The Mla Pathway Plays an Essential Role in the Intrinsic Resistance of Burkholderia cepacia Complex Species to Antimicrobials and Host Innate Components
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abstract
The outer membrane of Gram-negative bacteria acts as an effective barrier against toxic compounds, and therefore compromising this structure could increase sensitivity to currently available antibiotics. In this study, we show that the Mla pathway, a system involved in maintaining the integrity of the outer membrane, is genetically and functionally different in
Burkholderia cepacia
complex species compared to that in other proteobacteria. Mutants in
mla
genes of
Burkholderia cenocepacia
or
Burkholderia dolosa
were sensitive to Gram-positive antibiotics, while this effect was not observed in
Escherichia coli
or
Pseudomonas aeruginosa
. The Mla pathway in
Burkholderia
species may represent an ideal genus-specific target to address their intrinsic antimicrobial resistances.
