Opposing effects of carbon monoxide (CO) releasing molecule (CORM3) on activation of polymorphonuclear leukocytes (PMN) and endothelial cells (HUVEC) in sepsis.

Recently, it has been shown that CORM‐released CO can modulate inflammatory response. In this study we assessed the effects and potential mechanisms of water‐soluble CO‐releasing molecule, CORM3, in experimental model of sepsis. Sepsis in mice was induced by cecal ligation/puncture (CLP). CORM3 (3mg/kg; iv) was administered 15 min after CLP induction. PMN accumulation (MPO assay) in the lung was assessed 6 hr later. In in vitro experiments …