Group analysis identifies differentially elevated...

Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery

Abstract

AIM: To investigate early postoperative biomarkers for risk discrimination of advanced acute kidney injury (AKI). MATERIALS & METHODS: Postoperative plasma biomarkers including NGAL, h-FABP, CK-MB, hsTNT, NT-proBNP, IL-6, IL-10 and VEGF were analyzed using group-based method among 426 patients with AKI after cardiac surgery. RESULTS: Six patient groups with distinct biomarker patterns were identified. Individual biomarker displayed significant difference across the groups. The groups showed better discrimination for advanced AKI than any single biomarker either with or without adjusting for clinical variables. Average concentration of a single biomarker within each group, mortality and risk of a secondary outcome all demonstrated an approximately U-shaped relationship with proportion of advanced AKI within each group. CONCLUSION: The group-based analysis revealed that the order of the patient groups with an increasing likelihood of advanced AKI had a nonlinear relationship with average concentration of an individual biomarker, mortality and risk of other outcomes.

Authors

Lin H; Scherzer R; Philbrook HT; Coca SG; Wilson FP; Garg AX; Shlipak MG; Parikh CR

Journal

Biomarkers in Medicine, Vol. 11, No. 12, pp. 1091–1102

Publisher

Taylor & Francis

Publication Date

December 1, 2017

DOI

10.2217/bmm-2017-0060

ISSN

1752-0363

Associated Experts

Amit Garg

Assistant Professor (Part-Time), Faculty of Health Sciences

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Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery

Abstract

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Sustainable Development Goals (SDG)

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