Calcium-Channel Blocker–Clarithromycin Drug Interactions and Acute Kidney Injury

Abstract

IMPORTANCE: Calcium-channel blockers are metabolized by the cytochrome P450 3A4 (CYP3A4; EC 1.14.13.97) enzyme. Blood concentrations of these drugs may rise to harmful levels when CYP3A4 activity is inhibited. Clarithromycin is an inhibitor of CYP3A4 and azithromycin is not, which makes comparisons between these 2 macrolide antibiotics useful in assessing clinically important drug interactions. OBJECTIVE: To characterize the risk of acute …

Authors

Gandhi S; Fleet JL; Bailey DG; McArthur E; Wald R; Rehman F; Garg AX

Journal

JAMA: The Journal of the American Medical Association, Vol. 310, No. 23, pp. 2544–2553

Publisher

American Medical Association (AMA)

Publication Date

December 18, 2013

DOI

10.1001/jama.2013.282426

ISSN

0098-7484

Associated Experts

Amit Garg

Assistant Professor (Part-Time), Faculty of Health Sciences

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