M33 Long-term efficacy of nintedanib is maintained in patients with idiopathic pulmonary fibrosis (ipf) irrespective of dose: subgroup analysis of inpulsis-on

In the INPULSIS trials, nintedanib reduced the annual rate of decline in FVC versus placebo in patients with IPF (−113.6 versus −223.5 mL/year). Patients completing the 52 week treatment period could receive open-label nintedanib in an extension trial (INPULSIS-ON). Patients receiving nintedanib or placebo 150 mg bid at the end of INPULSIS received nintedanib 150 mg bid in INPULSIS-ON; patients receiving nintedanib or placebo 100 mg bid at the …