Diet‐induced obesity alters skeletal muscle satellite cell functional capacity.

Skeletal muscle satellite cells are integral for normal muscle growth. As skeletal muscle is the largest organ for blood glucose disposal, we were interested to ascertain whether a high fat diet (HFD) would negatively impact muscle satellite cells, and thus have a negative impact on skeletal muscle growth. Using isolated, intact single fibers, we found that the number of satellite cells in an 'activated state' was significantly enhanced (159 ± …