Characterizing Diabetic Myopathy: Muscle Contractility and Phenotype of Akita and STZ Diabetic Murine Models

Steptozotocin (STZ) induced diabetes impairs skeletal muscle function and alters muscle morphology, though recent evidence suggests these changes are a result of the STZ rather than diabetes per se . Thus, the phenotype of diabetic skeletal muscle remains unclear. The Akita mouse is a type 1 diabetes (T1DM) model that displays many similarities to human T1DM including adolescent onset. The purpose of the study was to determine the phenotype and …