Journal article
Chronic stress induces mast cell–dependent bacterial adherence and initiates mucosal inflammation in rat intestine
Abstract
BACKGROUND & AIMS: Chronic psychological stress is an important factor in relapses of intestinal disorders, but it remains unclear if stress can induce primary gut inflammation in a previously healthy host.
METHODS: Mast cell-deficient (Ws/Ws) rats and wild-type control (+/+) rats were submitted to water avoidance stress or sham stress (1 h/day) for 10 consecutive days, as a model of ongoing life stress.
Authors
Söderholm JD; Yang P; Ceponis P; Vohra A; Riddell R; Sherman PM; Perdue MH
Journal
Gastroenterology, Vol. 123, No. 4, pp. 1099–1108
Publisher
Elsevier
Publication Date
October 2002
DOI
10.1053/gast.2002.36019
ISSN
0016-5085