CD2+, CD3-, CD56/NCAM+ malignant lymphoma with TCRβ gene rearrangement: A case report Academic Article uri icon

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  • A case of CD56/NCAM+ malignant lymphoma is reported. Only a rare malignant lymphoma cell showed azurophilic granules in the cytoplasm of Giesma-stained preparations, while electron microscopic examination revealed occasional cytoplasmic granules with paracrystalline inclusions. The most common phenotype seen in NK lymphomas, CD2+, CD3-, CD56+, CD16-, CD57-, was present in the case. Cases with this phenotype have been interpreted to represent either true NK lymphoma or T-cell lymphoma with NK expression. Genotyping, where performed, has shown TCR germline configuration. Our case showed TCR beta rearrangement indicating that the above phenotype can be associated with a peripheral T-cell lymphoma.


  • Savilo, Elena
  • Meyer, Ralph
  • Soamboonsrup, Praniti
  • Sunisloe, Linda
  • Frank, George L
  • Simon, Gerard T
  • Neame, Peter B

publication date

  • November 1995