Relationship between spatial structure and pharmacological activity of a series of β‐adrenomimetics

AbstractAll equilibrium conformations of a series of N‐alkyl‐α‐alkyl derivatives of noradrenaline and their synthetic precursors—phenylaminoketones—have been calculated. It has been shown that spasmodic changes in bronchodilating activity of the catecholamines, observed with the increase in α‐alkyl substituent size, may arise from the difference in the ratio of diastereoisomers produced by reduction of aminoketones.

Relationship between spatial structure and pharmacological activity of a series of β‐adrenomimetics Journal Articles