Journal article
Interaction of oxytocin with Ca2+: II. Proton magnetic resonance and molecular modeling studies of conformations of the hormone and its Ca2+ complex
Abstract
Drastic changes in the CD and fluorescence spectra of oxytocin [cyclo(Cys1-Tyr2-Ile3-Gln4-Asn5-Cys6)-Pro7-Leu8-Gly 9-NH2] occur on binding Ca2+ in trifluoroethanol (Ananthanarayanan and Brimble, preceding paper). To further characterize the conformation of the Ca(2+)-bound hormone, we carried out 1H-nmr measurements in deuterated trifluorethanol of oxytocin and its 1:1 Ca2+ complex. The one-dimensional nmr data identified residues involved in …
Authors
Ananthanarayanan VS; Belciug M; Zhorov BS
Journal
Biopolymers, Vol. 40, No. 5, pp. 445–464
Publisher
Wiley
Publication Date
1996
DOI
10.1002/(sici)1097-0282(1996)40:5<445::aid-bip3>3.0.co;2-w
ISSN
0006-3525