Journal article
CD, 1H NMR and molecular modeling studies of the interaction of Ca2+ with substance P and Ala7‐substance P in a non‐polar solvent
Abstract
The biologically relevant conformation of substance P is likely to be dictated by the lipid milieu wherein the hormone would interact with its receptor. Assuming that specific constraints to the hormone structure may be imparted by its interaction with Ca2+ ions in the low dielectric lipid medium, the interaction of substance P and its inactive analog, Ala7-substance P, has been characterized in a lipid-mimetic solvent. Circular dichroism (CD) …
Authors
Qi X; Zhorov BS; Ananthanarayanan VS
Journal
Journal of Peptide Science, Vol. 6, No. 2, pp. 57–83
Publisher
Wiley
Publication Date
February 2000
DOI
10.1002/(sici)1099-1387(200002)6:2<57::aid-psc245>3.0.co;2-m
ISSN
1075-2617